Angel Toxicosis (天使の中毒症 Tenshi no Chuudokushou?), also known as Chronic Angelus Crystallus Inofficium, is the name which Refill Sage gave the name to Collet Brunel's illness since becoming a step closer to becoming an angel and losing one of her valuable nerves which allowed her to live. After releasing a seal, the angel toxicosis takes place and halts the processing within the relay routes of the nervous system in the host's body and takes them one step closer to becoming a lifeless being. Such an occurrence has a 1-in-a-million chance of happening. The disease can be cured with the use of a Rune Crest.